FM 3-11.9 POTENTIAL MILITARY CHEMICAL/BIOLOGICAL AGENTS AND COMPOUNDS (JANUARY 2005) - page 6

 

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FM 3-11.9 POTENTIAL MILITARY CHEMICAL/BIOLOGICAL AGENTS AND COMPOUNDS (JANUARY 2005) - page 6

 

 

Table G-5. Toxicity Estimates (Exposure Duration) for Military Chemical Compounds
ROE
Inhalation/Ocular
Lethal
Severe
Intolerable
Threshold
(LCt50)
(ECt50)
(ECt50)
(ECt50)
52,000-61,000P
7
CS
(5-90 minutes)
-
(1 minute)
-
0.15
0.002
- 0.004
CR
-
-
(1 minute)
(1 minute)
OC
None Recommended
-
-
-
11,000P
22 - 150P
< 1
DM
(2-240 minutes)
-
(1 minutes)
(1 minute)
12
DA
None Recommended
-
(2 minutes)
-
DC
None Recommended
None Recommended
-
-
10
Cl2
None Recommended
None Recommended
-
(seconds)
NOTES
P = Provisional
The existing estimates are not supported by the available data.
Toxicity estimates are followed by exposure duration in parenthesis.
Table G-6. Persistency of Selected CW Agents
CW Agents
Persistency1,2,3
CG
Nonpersistent
DP
Nonpersistent
GA
Nonpersistent
GB
Nonpersistent
GD
Nonpersistent
GF
Nonpersistent
VX
Persistent
Vx
Persistent
AC
Nonpersistent
CK
Nonpersistent
SA
Nonpersistent
HD
Persistent
HN-1
Persistent
HN-2
Persistent
HN-3
Persistent
HT
Persistent
L
Persistent
HL
Persistent
PD
Persistent
ED
Persistent
MD
Persistent
CX
Nonpersistent
BZ
Nonpersistent
NOTES
1Persistent Agent: A chemical agent that, when released, remains able
to cause casualties for more than 24 hours to several days or weeks. (JP
1-02)
2Nonpersistent Agent: A chemical agent that when released dissipates
and/or loses its ability to cause casualties after 10 to 15 minutes. (JP 1-
02)
Note: In general, as temperature increases, persistency decreases.
G-18
Choking Agents
10000
1000
CG
Water
DP
100
10
1
0.1
-30
-10
10
30
50
70
90
110
130
Temperature (oC)
Figure G-1. Vapor Pressure of Choking Agents1
Nerve Agents
1000
100
Water
GB
GD
GF
GA E
A 1699
VX
10
1
0.1
0.01
0.001
-40
-20
0
20
40
60
80
100
120
140
160
180
200
220
240
Temperature (oC)
Figure G-2. Vapor Pressure of Nerve Agents1
Blood Agents
1000
SA
CK
AC
Water
100
10
1
-120
-100
-80
-60
-40
-20
0
20
40
60
80
100
120
Temperature (oC)
Figure G-3. Vapor Pressure of Blood Agents1
Blister Agents
1000
Water
MD
CX
L
HD
100
10
HN-3
PD
ED
HN-1
1
HN-2
0.1
HT
HL
0.01
-20
0
20
40
60
80
100
120
140
160
180
200
Temperature (oC)
Figure G-4. Vapor Pressure of Blister Agents1
Incapacitating Agent (BZ)
1000
Water
100
10
1
0.1
BZ
0.01
0.001
0
20
40
60
80
100
120
140
160
180
Temperature (oC)
Figure G-5. Vapor Pressure of Incapacitating Agent (BZ)1
Riot Control Agent (Capsaicin)
1000
100
Water
10
1
0.1
Capsaicin
0.01
0.001
-20
0
20
40
60
80
100
120
140
160
180
200
Temperature (oC)
Figure G-6. Vapor Pressure of Riot Control Agent (Capsaicin)1
Respiratory Irritants
10000
Chlorine
1000
Water
100
DA
10
DC
DM
1
0.1
-50
-25
0
25
50
75
100
125
150
175
200
225
250
275
Temperature (oC)
Figure G-7. Vapor Pressure of Respiratory Irritants1
NOTES
1Patrice L. Abercombie, Physical Property Data Review of Selected Chemical Agents and
Related Compounds, September 2003.
G-26
Appendix H
TOXICITY PROFILE ESTIMATES
1.
Background
This appendix gives the Ct profile estimates and the MV profile estimates (when
available) for selected CW agents.
2.
Choking Agents
a.
CG Profile. Table H-1 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to CG.
Table H-1. CG Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
1500
750
10
2250
10
1500
150
15
1500
30
1500
50
30
750
60
1500
25
50
450
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1
DOC: Moderate
b.
DP Profile. Table H-2 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to DP.
Table H-2. DP Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
1500
750
10
2250
10
1500
150
15
1500
30
1500
50
30
750
60
1500
25
50
450
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
3.
Nerve Agents
a.
GA Profile.
(1)
Table H-3 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to GA.
Table H-3. GA Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
70
35
10
100
10
120
12
15
70
30
170
6.0
30
35
60
220
3.6
50
20
120
270
2.3
240
345
1.4
360
395
1.1
Selected Toxicology Information
Probit Slope: 12
TLE: 1.5
DOC: Moderate
H-1
(2)
Table H-4 provides toxicity estimates for a lethal dose from a percutaneous
vapor exposure to GA. Personnel are masked with bare skin.
Table H-4. GA Profile Estimates (Lethal Dose, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
LCt50
Concentration
Exposure
LCt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
15,000
7500
2
7500
3750
10
15,000
1500
10
7500
750
30
15,000
500
30
7500
250
60
15,000
250
60
7500
125
120
15,000
125
120
7500
60
240
15,000
60
240
7500
30
360
15,000
40
360
7500
20
Selected Toxicology Information
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
(3)
Table H-5 provides toxicity estimates for severe effects from an
inhalation/ocular vapor exposure to GA.
Table H-5. GA Profile Estimates (Severe Effects, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
ECt50 (mg-min/m3)
2
50
25
10
75
10
85
8.5
15
50
30
120
4.1
30
25
60
155
2.6
50
15
120
200
1.6
240
250
1.0
360
280
0.8
Selected Toxicology Information
Probit Slope: 10
TLE: 1.5
DOC: Moderate
(4)
Table H-6 provides toxicity estimates for severe effects from a percutaneous
vapor exposure to GA. Personnel are masked with bare skin.
Table H-6. GA Profile Estimates (Severe Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
ECt50
Concentration
Exposure
ECt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
12,000
6000
2
6000
3000
10
12,000
1200
10
6000
600
30
12,000
400
30
6000
200
60
12,000
200
60
6000
100
120
12,000
100
120
6000
50
240
12,000
50
240
6000
25
360
12,000
35
360
6000
15
Selected Toxicology Information
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
H-2
(5)
Table H-7 provides toxicity estimates for threshold effects from a
percutaneous vapor exposure to GA. Personnel are masked with bare skin.
Table H-7. GA Profile Estimates (Threshold Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
ECt50
Concentration
Exposure
ECt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
2000
1000
2
1000
500
10
2000
200
10
1000
100
30
2000
65
30
1000
30
60
2000
30
60
1000
15
120
2000
15
120
1000
10
240
2000
10
240
1000
5
360
2000
5
360
1000
2.5
Selected Toxicology Information
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Moderate
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Moderate
(6)
Table H-8 provides toxicity estimates for mild effects from an
inhalation/ocular vapor exposure to GA. Mild effects include miosis and rhinorrhea.
Table H-8. GA Profile Estimates (Mild Effects, Inhalation/Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
0.4
0.16
10
0.6
0.07
30
0.9
0.03
60
1.1
0.02
120
1.4
0.01
240
1.7
0.007
360
2.0
0.005
Selected Toxicology Information
Probit Slope: 10
TLE: 1.5
DOC: Low
(7)
Figure H-1 is a graphical representation of GA vapor Ct profile for dosage
from an inhalation/ocular exposure.
00
Upper Band: LCt16 and LCt84 Region
10
Line: ECt16 (Severe) [roughly LCt01]
Lower Band: ECt16 and ECt84 Region
for miosis (pupil shrinkage)
1
0.1
1
10
100
Time (minutes)
Extrapolation Beyond 10 minutes: Based
on experimental data out to 120 minutes.
Figure H-1. GA Vapor: Dosage versus Exposure Duration
H-3
(8)
Figure H-2 is a graphical representation of GA vapor Ct profile for
concentration from an inhalation/ocular exposure.
10
1
0.1
Upper Band: LCt16 and LCt84 Region
0.01
Line: ECt16 (Severe) [roughly LCt01]
Lower Band: ECt16 and ECt84 Region for
miosis (pupil shrinkage)
0.001
1
10
100
Time (minutes)
Extrapolation Beyond 10 minutes: Based on
experimental data out to 120 minutes.
Figure H-2. GA Vapor: Concentration versus Exposure Duration
b.
GB Profile.
(1)
Table H-9 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to GB.
Table H-9. GB Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
35
17.5
10
50
10
60
6.0
15
35
30
86
3.0
30
17
60
110
1.8
50
10
120
140
1.1
240
175
0.7
360
200
0.6
Selected Toxicology Information
Probit Slope: 12
TLE: 1.5
DOC: Moderate
H-4
(2)
Table H-10 provides toxicity estimates for a lethal dose from a
percutaneous vapor exposure to GB. Personnel are masked with bare skin.
Table H-10. GB Profile Estimates (Lethal Dose, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
LCt50
Concentration
Exposure
LCt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
12,000
6000
2
6000
3000
10
12,000
1200
10
6000
600
30
12,000
400
30
6000
200
60
12,000
200
60
6000
100
120
12,000
100
120
6000
50
240
12,000
50
240
6000
25
360
12,000
30
360
6000
15
Selected Toxicology Information
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
(3)
Table H-11 provides toxicity estimates for severe effects from an
inhalation/ocular vapor exposure to GB.
Table H-11. GB Profile Estimates (Severe Effects, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
ECt50 (mg-min/m3)
2
25
12.5
10
37
10
45
4.3
15
25
30
60
2.1
30
12
60
80
1.3
50
7.5
120
100
0.8
240
125
0.5
360
140
0.4
Selected Toxicology Information
Probit Slope: 12
TLE: 1.5
DOC: Moderate
(4)
Table H-12 provides toxicity estimates for severe effects from a
percutaneous vapor exposure to GB, and personnel are masked with bare skin.
Table H-12. GB Profile Estimates (Severe Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
ECt50
Concentration
Exposure
ECt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
8000
4000
2
4000
2000
10
8000
800
10
4000
400
30
8000
250
30
4000
125
60
8000
130
60
4000
65
120
8000
65
120
4000
30
240
8000
30
240
4000
15
360
8000
20
360
4000
10
Selected Toxicology Information
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
H-5
(5)
Table H-13 provides toxicity estimates for threshold effects from a
percutaneous vapor exposure to GB. Personnel are masked with bare skin.
Table H-13. GB Profile Estimates (Threshold Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
ECt50
Concentration
Exposure
ECt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
1200
600
2
600
300
10
1200
120
10
600
60
30
1200
40
30
600
20
60
1200
20
60
600
10
120
1200
10
120
600
5
240
1200
5
240
600
2.5
360
1200
3
360
600
1.5
Selected Toxicology Information
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Moderate
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
(6)
Table H-14 provides toxicity estimates for mild effects from an
inhalation/ocular vapor exposure to GB.
Table H-14. GB Profile Estimates (Mild Effects, Inhalation/Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
0.4
0.18
10
0.6
0.06
30
0.9
0.03
60
1.1
0.02
120
1.4
0.01
240
1.7
0.007
360
2.0
0.005
Selected Toxicology Information
Probit Slope: 10
TLE: 1.5
DOC: Moderate
(7)
Figure H-3 is a graphical representation of GB vapor Ct profile for dosage
from an inhalation/ocular exposure.
100
10
Upper Band: LCt16 and LCt84 Region
Line: ECt16 (Severe)[roughly LCt01}
Lower Band: ECt16 and ECt84 Region
for miosis (pupil shrinkage)
1
0.1
1
10
100
Extrapolation Beyond 10 minutes: Based
Time (minutes)
on experimental data out to 360 minutes.
Figure H-3. GB Vapor: Dosage versus Exposure Duration
H-6
(8)
Figure H-4 is a graphical representation of GB vapor Ct profile for
concentration from an inhalation/ocular exposure.
10
1
0.1
Upper Band: LCt16 and LCt84 Region
0.01
Line: ECt16 (Severe) [roughly LCt01]
Lower Band: ECt16 and ECt84 Region
for miosis (pupil shrinkage)
0.001
1
10
100
Time (minutes)
Extrapolation Beyond 10 minutes: Based
on experimental data out to 360 minutes.
Figure H-4. GB Vapor: Concentration versus Exposure Duration
c.
GD Profile.
(1)
Table H-15 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to GD.
Table H-15. GD Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
35
17.5
10
50
10
50
4.8
15
35
30
60
2.0
30
15
60
70
1.2
50
10
120
80
0.7
240
90
0.4
360
100
0.3
Selected Toxicology Information
Probit Slope: 12
TLE: 1.25
DOC: Low
H-7
(2)
Table H-16 provides toxicity estimates for a lethal dose from a
percutaneous vapor exposure to GD. Personnel are masked with bare skin.
Table H-16. GD Profile Estimates (Lethal Dose, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
LCt50
Concentration
Exposure
LCt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
3000
1500
2
1500
750
10
3000
300
10
1500
375
30
3000
100
30
1500
150
60
3000
50
60
1500
25
120
3000
25
120
1500
12
240
3000
12
240
1500
5
360
3000
5
360
1500
2
Selected Toxicology Information
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Low
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Low
(3)
Table H-17 provides toxicity estimates for severe effects from an
inhalation/ocular vapor exposure to GD.
Table H-17. GD Profile Estimates (Severe Effects, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
ECt50 (mg-min/m3)
2
25
12.5
10
35
10
35
3.5
15
25
30
45
1.5
30
10
60
50
0.8
50
7.5
120
55
0.4
240
65
0.3
360
70
0.2
Selected Toxicology Information
Probit Slope: 12
TLE: 1.25
DOC: Low
(4)
Table H-18 provides toxicity estimates for severe effects from a
percutaneous vapor exposure to GD. Personnel are masked with bare skin.
Table H-18. GD Profile Estimates (Severe Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
ECt50
Concentration
Exposure
ECt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
2000
1000
2
1000
500
10
2000
200
10
1000
100
30
2000
60
30
1000
30
60
2000
30
60
1000
15
120
2000
15
120
1000
7.5
240
2000
7.5
240
1000
5
360
2000
5
360
1000
2.5
Selected Toxicology Information
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Low
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Low
H-8
(5)
Table H-19 provides toxicity estimates for threshold effects from a
percutaneous vapor exposure to GD. Personnel are masked with bare skin.
Table H-19. GD Profile Estimates (Threshold Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
ECt50
Concentration
Exposure
ECt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
300
150
2
150
75
10
300
30
10
150
15
30
300
10
30
150
5
60
300
5
60
150
2.5
120
300
2.5
120
150
1.25
240
300
1.25
240
150
0.5
360
300
0.6
360
150
0.3
Selected Toxicology Information
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Low
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Low
(6)
Table H-20 provides a toxicity estimate given for mild effects from an
inhalation/ocular vapor exposure to GD.
Table H-20. GD Profile Estimates (Mild Effects, Inhalation/Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
0.2
0.1
10
0.3
0.03
30
0.4
0.01
60
0.5
0.009
120
0.6
0.005
240
0.8
0.003
360
0.9
0.0025
Selected Toxicology Information
Probit Slope: 10
TLE: 1.4
DOC: Low
(7)
Figure H-5 is a graphical representation of Ct profile for GD vapor dosage
from an inhalation/ocular exposure.
100
10
Upper Band: LCt16 and LCt84 Region
Line: ECt16 (Severe) [roughly LCt01]
Lower Band: ECt16 and ECt84 Region for
miosis (pupil shrinkage)
1
0.1
1
10
100
Extrapolation Beyond 10 minutes: Based on
Time (minutes)
n for GF - No experimental data available.
Figure H-5. GD Vapor: Dosage versus Exposure Duration
H-9
(8)
Figure H-6 is a graphical representation of Ct profile for GD vapor
concentration from an inhalation/ocular exposure.
10
1
0.1
0.01
Upper Band: LCt16 and LCt84 Region
Line: ECt16 (Severe)[roughly LCt01]
Lower Band: ECt16 and ECt84 Region
for miosis (pupil shrinkage).
0.001
1
10
100
Extrapolation Beyond 10 minutes: No experimental data
Time (minutes)
available - based on n for GF.
Figure H-6. GD Vapor: Concentration versus Exposure Duration
d.
GF Profile.
(1)
Table H-21 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to GF.
Table H-21. GF Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
35
17.5
10
50
10
48
4.8
15
35
30
60
2.0
30
17
60
69
1.0
50
10
120
79
0.7
240
91
0.4
360
99
0.3
Selected Toxicology Information
Probit Slope: 12
TLE: 1.25
DOC: Moderate
(2)
Table H-22 provides toxicity estimates for a lethal dose from a
percutaneous vapor exposure to GF. Personnel are masked with bare skin.
Table H-22. GF Profile Estimates (Lethal Dose, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
LCt50
Concentration
Exposure
LCt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
3000
1500
2
1500
7500
10
3000
300
10
1500
375
30
3000
100
30
1500
150
60
3000
50
60
1500
25
120
3000
25
120
1500
12
240
3000
12
240
1500
5
360
3000
5
360
1500
2
Selected Toxicology Information
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
H-10
(3)
Table H-23 provides toxicity estimates for severe effects from an
inhalation/ocular vapor exposure to GF.
Table H-23. GF Profile Estimates (Severe Effects, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
ECt50 (mg-min/m3)
2
25
12.5
10
35
10
35
3.5
15
25
30
45
1.5
30
10
60
50
0.8
50
7.5
120
55
0.4
240
65
0.3
360
70
0.2
Selected Toxicology Information
Probit Slope: 12
TLE: 1.25
DOC: Moderate
(4)
Table H-24 provides toxicity estimates for severe effects from a
percutaneous vapor exposure to GF. Personnel are masked with bare skin.
Table H-24. GF Profile Estimates (Severe Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
ECt50
Concentration
Exposure
ECt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
2000
1000
2
1000
500
10
2000
200
10
1000
100
30
2000
60
30
1000
30
60
2000
30
60
1000
15
120
2000
15
120
1000
7.5
240
2000
7.5
240
1000
5
360
2000
5
360
1000
2.5
Selected Toxicology Information
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
(5)
Table H-25 provides toxicity estimates for threshold effects from a
percutaneous vapor exposure to GF. Personnel are masked with bare skin.
Table H-25. GF Profile Estimates (Threshold Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
ECt50
Concentration
Exposure
ECt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
300
150
2
150
75
10
300
30
10
150
15
30
300
10
30
150
5
60
300
5
60
150
2.5
120
300
2.5
120
150
1.25
240
300
1.25
240
150
0.5
360
300
0.6
360
150
0.3
Selected Toxicology Information
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Low
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Low
H-11
(6)
Table H-26 provides toxicity estimates for mild effects from an
inhalation/ocular vapor exposure to GF.
Table H-26. GF Profile Estimates (Mild Effects, Inhalation/Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
0.2
0.1
10
0.3
0.03
30
0.4
0.01
60
0.5
0.009
120
0.6
0.005
240
0.8
0.003
360
0.9
0.0025
Selected Toxicology Information
Probit Slope: 10
TLE: 1.4
DOC: Low
(7)
Figure H-7 is a graphical representation Ct profile for GF vapor dosage
from an inhalation/ocular exposure.
100
10
Upper Band: LCt16 and LCt84 Region
Line: ECt16 (Severe) [roughly LCt01]
Lower Band: ECt16 and ECt84
Region
for miosis (pupil shrinkage)
1
0.1
1
10
100
Extrapolation Beyond 10 minutes: Based
Time (minutes)
on experimental data to 240 minutes.
Figure H-7. GF Vapor: Dosage versus Exposure Duration
H-12
(8)
Figure H-8 is a graphical representation of Ct profile for GF vapor
concentration from an inhalation/ocular exposure.
Upper Band: LCt16 and LCt84 Region
10
Line: ECt16 (Severe) {roughly LCt01)
Lower Band: ECt16 and ECt84 Region
for miosis (pupil shrinkage)
1
0.1
0.01
0.00
1
10
100
Extrapolation Beyond 10 minutes: Based
Time (minutes)
on experimental data to 240 minutes.
Figure H-8. GF Vapor: Concentration versus Exposure Duration
e.
VX Profile.
(1)
Table H-27 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to VX.
Table H-27. VX Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
15
7.50
10
20
10
15
1.50
15
15
30
15
0.50
30
5
60
15
0.25
50
4
120
15
0.12
240
15
0.06
360
15
0.04
Selected Toxicology Information
Probit Slope: 6
TLE: 1
DOC: Low (LCt50 could be less)
H-13
(2)
Table H-28 provides toxicity estimates for a lethal dose from a
percutaneous vapor exposure to VX. Personnel are masked with bare skin.
Table H-28. VX Profile Estimates (Lethal Dose, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
LCt50
Concentration
Exposure
LCt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
150
75
2
75
38
10
150
15
10
75
7.5
30
150
5
30
75
2.5
60
150
2.5
60
75
1.3
120
150
1.25
120
75
0.6
240
150
0.6
240
75
0.3
360
150
0.4
360
75
0.2
Selected Toxicology Data
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Low
Probit Slope: 5
TLE: 1 (Assumed)
DOC: Low
(3)
Table H-29 provides toxicity estimates for severe effects from an
inhalation/ocular vapor exposure to VX.
Table H-29. VX Profile Estimates (Severe Effects, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
ECt50 (mg-min/m3)
2
10
5
10
15
10
10
1
15
10
30
10
0.3
30
5
60
10
0.2
50
3
120
10
0.1
240
10
0.04
360
10
0.03
Selected Toxicology Estimates
Probit Slope: 6
TLE: 1
DOC: Low (ECt50 could be less)
(4)
Table H-30 provides toxicity estimates for severe effects from a
percutaneous vapor exposure to VX. Personnel are masked with bare skin.
Table H-30. VX Profile Estimates (Severe Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
ECt50
Concentration
Exposure
ECt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
25
12.5
2
12
2.5
10
25
2.5
10
12
1.25
30
25
1.25
30
12
0.63
60
25
0.63
60
12
0.30
120
25
0.30
120
12
0.16
240
25
0.16
240
12
0.07
360
25
0.07
360
12
0.04
Selected Toxicology Information
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Moderate
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Low
H-14
(5)
Table H-31 provides toxicity estimates for threshold effects from a
percutaneous vapor exposure to VX. Personnel are masked with bare skin.
Table H-31. VX Profile Estimates (Threshold Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
ECt50
Concentration
Exposure
ECt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
10
5
2
5
2.5
10
10
1
10
5
0.5
30
10
0.3
30
5
0.15
60
10
0.15
60
5
0.08
120
10
0.08
120
5
0.04
240
10
0.04
240
5
0.02
360
10
0.03
360
5
0.01
Selected Toxicology Information
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Moderate
Probit Slope: 6
TLE: 1 (Assumed)
DOC: Low
(6)
Table H-32 provides toxicity estimates for mild effects from an
inhalation/ocular vapor exposure to VX.
Table H-32. VX Profile Estimates (Mild Effects, Inhalation/Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
0.1
0.05
10
0.1
0.01
30
0.1
0.003
60
0.1
0.002
120
0.1
0.001
240
0.1
0.0004
360
0.1
0.0003
Selected Toxicology Information
Probit Slope: 4
TLE: 1 (Assumed)
DOC: Low
(7)
Figure H-9 is a graphical representation of Ct profile for VX vapor dosage
from an inhalation/ocular exposure.
10
Upper Band: LCt16 and LCt84 Region
Line: ECt16 (Severe) [roughly LCt01]
1
Lower Band: ECt16 and ECt84 Region for
miosis (pupil shrinkage)
0.1
0.0
1
10
100
Extrapolation Beyond 10 minutes: From poor
Time (minutes)
experimental data to 360 minutes, n=1.
Figure H-9. VX Vapor: Dosage versus Exposure Duration
H-15
(8)
Figure H-10 is a graphical representation of Ct profile for VX vapor
concentration from an inhalation/ocular exposure.
Upper Band: LCt16 and LCt84 Region
10
Line: ECt16 (Severe) [roughly LCt01]
Lower Band: ECt16 and ECt84 Region
for miosis (pupil shrinkage)
1
0.1
0.01
0.001
0.0001
1
10
100
Extrapolation Beyond 10 minutes: From poor
Time (minutes)
experimental data to 360 minutes, n=1.
Figure H-10. VX Vapor: Concentration versus Exposure Duration
4.
Blood Agents
a.
AC Profile. Table H-33 provides provisional toxicity estimates for a lethal dose
from an inhalation/ocular vapor exposure to AC.
Table H-33. AC Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
2860
1430
10
4290
10
6070
607
15
2860
30
20,630
685
30
1430
50
858
Selected Toxicology Inforamtion
Probit Slope: 10
TLE: 1.85
DOC: Low
b.
SA Profile. Table H-34 provides provisional toxicity estimates for a lethal dose
from an inhalation/ocular vapor exposure to SA.
Table H-34. SA Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
1
6000
6000
10
11,250
2
7500
3750
15
7500
5
9500
1900
30
3750
10
11,500
1150
50
2250
20
14,000
700
30
16,000
530
60
19,500
325
120
23,500
195
240
26,500
120
Selected Toxicology Information
Probit Slope: Not Calculated
TLE: 1.4
DOC: Low
H-16
5.
Blister Agents
a.
HD Profile.
(1)
Table H-35 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to HD.
Table H-35. HD Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
1000
500
10
1500
10
1710
170
15
1000
30
2466
80
30
500
60
3107
50
50
300
120
3915
30
240
4932
20
360
5646
15
Selected Toxicology Information
Probit Slope: 6
TLE: 1.5
DOC: Low
(2)
Table H-36 provides toxicity estimates for a lethal dose from a
percutaneous vapor exposure to HD. Personnel are masked with clothed skin.
Table H-36. HD Profile Estimates (Lethal Dose, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
LCt50
Concentration
Exposure
LCt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
10,000
5000
2
5000
2500
10
10,000
1000
10
5000
500
30
10,000
330
30
5000
165
60
10,000
165
60
5000
85
120
10,000
85
120
5000
40
240
10,000
40
240
5000
20
360
10,000
30
360
5000
15
Selected Toxicology Information
Probit Slope: 7
TLE: 1 (Assumed)
DOC: Low
Probit Slope: 7
TLE: 1 (Assumed)
DOC: Low
True human LCt50 may be lower.
(3)
Table H-37 provides toxicity estimates for severe effects (vesication) from a
percutaneous vapor exposure to HD. Personnel are masked with clothed skin.
Table H-37. HD Profile Estimates (Severe Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
ECt50
Concentration
Exposure
ECt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
500
250
2
200
100
10
500
50
10
200
20
30
500
15
30
200
5
60
500
10
60
200
3
120
500
5
120
200
1.7
240
500
2
240
200
0.8
360
500
1.4
360
200
0.6
Selected Toxicology Information
Probit Slope: 3
TLE: 1 (Assumed)
DOC: Moderate
Probit Slope: 3
TLE: 1 (Assumed)
DOC: Moderate
True human ECt50 may be lower.
H-17
(4)
Table H-38 provides toxicity estimates for severe effects (eyes) from an
ocular vapor exposure to HD.
Table H-38. HD Profile Estimates (Severe Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
75
37.5
10
75
7.5
30
75
2.5
60
75
1.25
120
75
0.63
240
75
0.31
360
75
0.21
Selected Toxicology Information
Probit Slope: 3
TLE: 1
DOC: High
(5)
Table H-39 provides toxicity estimates for mild effects from a percutaneous
vapor exposure to HD. Personnel are masked with clothed skin.
Table H-39. HD Profile Estimates (Mild Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure
ECt50
Concentration
Exposure
ECt50
Concentration
Duration (min)
(mg-min/m3)
(mg/m3)
Duration (min)
(mg-min/m3)
(mg/m3)
2
50
25
2
25
12.5
10
50
5
10
25
2.5
30
50
1.7
30
25
0.8
60
50
0.8
60
25
0.4
120
50
0.4
120
25
0.2
240
50
0.2
240
25
0.1
360
50
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: 3
TLE: 1
DOC: Moderate
Probit Slope: 3
TLE: 1
DOC: Moderate
(6)
Table H-40 provides toxicity estimates for mild effects (eyes) from an ocular
vapor exposure to HD.
Table H-40. HD Profile Estimates (Mild Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
25
12.5
10
25
2.5
30
25
0.8
60
25
0.4
120
25
0.2
240
25
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: 3
TLE: 1
DOC: High
H-18
(7)
Figure H-11 is a graphical representation of Ct profile for HD vapor dosage
from an inhalation/ocular exposure.
10000
For hot conditions, PC Severe
Region (Middle Band) should be
shifted downward by a factor of 3.
1000
100
Upper Band: LCt16 and LCt84 (IH)
Extrapolation Beyond 10 minutes: Based
Middle Band: ECt16 and ECt84
(PC severe)
on experimental data to 360 minutes.
Lower Band: ECt16 and ECt84 (OC severe)
10
1
10
100
Time (minutes)
Figure H-11. HD Vapor: Dosage versus Exposure Duration
(8)
Figure H-12 is a graphical representation of Ct profile for HD vapor
concentration for inhalation/ocular exposure.
1000
For hot conditions, PC
Severe Region (middle
band) should be shifted
downward by a factor of 3.
100
10
1
Upper Band: LCt16 and LCt84 (IH)
Middle Band: ECt16 and ECt84 (PC severe)
Lower Band: ECt16 and ECt84 (OC severe)
0.1
1
10
100
Extrapolation Beyond 10 Minutes: Based on
experimental data to 360 minutes
Time (minutes)
Figure H-12. HD Vapor: Concentration versus Exposure Duration
H-19
b.
HN-1 Profile.
(1)
Table H-41 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to HN-1.
Table H-41. HN-1 Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
1000
500
10
1500
10
1000
100
15
1000
30
1000
35
30
500
60
1000
15
50
300
120
1000
10
240
1000
5
360
1000
2.5
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(2)
Table H-42 provides toxicity estimates for a lethal dose from a
percutaneous vapor exposure to HN-1. Personnel are masked.
Table H-42. HN-1 Profile Estimates (Lethal Dose, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
LCt50
Concentration
Exposure Duration
LCt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
10,000
5000
2
5000
2500
10
10,000
1000
10
5000
500
30
10,000
330
30
5000
165
60
10,000
165
60
5000
85
120
10,000
85
120
5000
40
240
10,000
40
240
5000
20
360
10,000
30
360
5000
15
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(3)
Table H-43 provides toxicity estimates for severe effects (vesication) from a
percutaneous vapor exposure to HN-1. Personnel are masked.
Table H-43. HN-1 Profile Estimates (Severe Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
ECt50
Concentration
Exposure Duration
ECt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
500
250
2
200
100
10
500
50
10
200
20
30
500
15
30
200
5
60
500
10
60
200
3
120
500
5
120
200
1.7
240
500
2
240
200
0.8
360
500
1.4
360
200
0.6
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
H-20
(4)
Table H-44 provides toxicity estimates for severe effects on eyes from an
ocular vapor exposure to HN-1.
Table H-44. HN-1 Profile Estimates (Severe Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
75
37.5
10
75
7.5
30
75
2.5
60
75
1.25
120
75
0.63
240
75
0.31
360
75
0.21
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(5)
Table H-45 provides toxicity estimates for mild effects from a percutaneous
vapor exposure to HN-1. Personnel are masked.
Table H-45. HN-1 Profile Estimates (Mild Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
ECt50
Concentration
Exposure Duration
ECt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
50
25
2
25
12.5
10
50
5
10
25
2.5
30
50
1.7
30
25
0.8
60
50
0.8
60
25
0.4
120
50
0.4
120
25
0.2
240
50
0.2
240
25
0.1
360
50
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(6)
Table H-46 provides toxicity estimates for mild effects on eyes from an
ocular vapor exposure to HN-1.
Table H-46. HN-1 Profile Estimates (Mild Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
25
12.5
10
25
2.5
30
25
0.8
60
25
0.4
120
25
0.2
240
25
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
H-21
c.
HN-2 Profile.
(1)
Table H-47 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to HN-2.
Table H-47. HN-2 Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
1000
500
10
1500
10
1000
100
15
1000
30
1000
35
30
500
60
1000
15
50
300
120
1000
10
240
1000
5
360
1000
2.5
Selected Toxicology Information
Probit Slope: Unknown
TLE: Unknown
DOC: Low
(2)
Table H-48 provides toxicity estimates for a lethal dose from a
percutaneous vapor exposure to HN-2. Personnel are masked.
Table H-48. HN-2 Profile Estimates (Lethal Dose, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
LCt50
Concentration
Exposure Duration
LCt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
10,000
5000
2
5000
2500
10
10,000
1000
10
5000
500
30
10,000
330
30
5000
165
60
10,000
165
60
5000
85
120
10,000
85
120
5000
40
240
10,000
40
240
5000
20
360
10,000
30
360
5000
15
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(3)
Table H-49 provides toxicity estimates for severe effects (vesication) for
exposure to HN-2. Personnel are masked.
Table H-49. HN-2 Profile Estimates (Severe Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
ECt50
Concentration
Exposure Duration
ECt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
500
250
2
200
100
10
500
50
10
200
20
30
500
15
30
200
5
60
500
10
60
200
3
120
500
5
120
200
1.7
240
500
2
240
200
0.8
360
500
1.4
360
200
0.6
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
H-22
(4)
Table H-50 provides toxicity estimates for severe effects on eyes from an
ocular vapor exposure to HN-2.
Table H-50. HN-2 Profile Estimates (Severe Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
75
37.5
10
75
7.5
30
75
2.5
60
75
1.25
120
75
0.63
240
75
0.31
360
75
0.21
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(5)
Table H-51 provides toxicity estimates for mild effects from a percutaneous
vapor exposure to HN-2. Mild effects include erythema, itching and some pain. Personnel
are masked.
Table H-51. HN-2 Profile Estimates (Mild Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
ECt50
Concentration
Exposure Duration
ECt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
50
25
2
25
12.5
10
50
5
10
25
2.5
30
50
1.7
30
25
0.8
60
50
0.8
60
25
0.4
120
50
0.4
120
25
0.2
240
50
0.2
240
25
0.1
360
50
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(6)
Table H-52 provides toxicity estimates for mild effects on eyes from an
ocular vapor exposure to HN-2.
Table H-52. HN-2 Profile Estimates (Mild Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
25
12.5
10
25
2.5
30
25
0.8
60
25
0.4
120
25
0.2
240
25
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
H-23
d.
HN-3 Profile.
(1)
Table H-53 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to HN-3.
Table H-53. HN-3 Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
1000
500
10
1500
10
1000
100
15
1000
30
1000
35
30
500
60
1000
15
50
300
120
1000
10
240
1000
5
360
1000
2.5
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(2)
Table H-54 provides toxicity estimates given for a lethal dose from a
percutaneous vapor exposure to HN-3. Personnel are masked.
Table H-54. HN-3 Profile Estimates (Lethal Dose, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
LCt50
Concentration
Exposure Duration
LCt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
10,000
5000
2
5000
2500
10
10,000
1000
10
5000
500
30
10,000
330
30
5000
165
60
10,000
165
60
5000
85
120
10,000
85
120
5000
40
240
10,000
40
240
5000
20
360
10,000
30
360
5000
15
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(3)
Table H-55 provides toxicity estimates for severe effects (vesication) from a
percutaneous vapor exposure to HN-3. Personnel are masked.
Table H-55. HN-3 Profile Estimates (Severe Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
ECt50
Concentration
Exposure Duration
ECt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
500
250
2
200
100
10
500
50
10
200
20
30
500
15
30
200
5
60
500
10
60
200
3
120
500
5
120
200
1.7
240
500
2
240
200
0.8
360
500
1.4
360
200
0.6
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
H-24
(4)
Table H-56 provides toxicity estimates given for severe effects on eyes from
an ocular vapor exposure to HN-3.
Table H-56. HN-3 Profile Estimates (Severe Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
75
37.5
10
75
7.5
30
75
2.5
60
75
1.25
120
75
0.63
240
75
0.31
360
75
0.21
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(5)
Table H-57 provides toxicity estimates for mild effects from a percutaneous
vapor exposure to HN-3. Personnel are masked.
Table H-57. HN-3 Profile Estimates (Mild Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
ECt50
Concentration
Exposure Duration
ECt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
50
25
2
25
12.5
10
50
5
10
25
2.5
30
50
1.7
30
25
0.8
60
50
0.8
60
25
0.4
120
50
0.4
120
25
0.2
240
50
0.2
240
25
0.1
360
50
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(6)
Table H-58 provides toxicity estimates for mild effects on eyes from an
ocular vapor exposure to HN-3.
Table H-58. HN-3 Profile Estimates (Mild Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
25
12.5
10
25
2.5
30
25
0.8
60
25
0.4
120
25
0.2
240
25
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
H-25
e.
HT Profile.
(1)
Table H-59 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to HT.
Table H-59. HT Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
1000
500
10
1500
10
1000
100
15
1000
30
1000
35
30
500
60
1000
15
50
300
120
1000
10
240
1000
5
360
1000
2.5
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(2)
Table H-60 provides toxicity estimates for a lethal dose from a
percutaneous vapor exposure to HT. Personnel are masked.
Table H-60. HT Profile Estimates (Lethal Dose, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
LCt50
Concentration
Exposure Duration
LCt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
10,000
5000
2
5000
2500
10
10,000
1000
10
5000
500
30
10,000
330
30
5000
165
60
10,000
165
60
5000
85
120
10,000
85
120
5000
40
240
10,000
40
240
5000
20
360
10,000
30
360
5000
15
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(3)
Table H-61 provides toxicity estimates for severe effects (vesication) from a
percutaneous vapor exposure to HT. Personnel are masked.
Table H-61. HT Profile Estimates (Severe Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
ECt50
Concentration
Exposure Duration
ECt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
500
250
2
200
100
10
500
50
10
200
20
30
500
15
30
200
5
60
500
10
60
200
3
120
500
5
120
200
1.7
240
500
2
240
200
0.8
360
500
1.4
360
200
0.6
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
H-26
(4)
Table H-62 provides toxicity estimates for severe effects on eyes from an
ocular vapor exposure to HT.
Table H-62. HT Profile Estimates (Severe Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
75
37.5
10
75
7.5
30
75
2.5
60
75
1.25
120
75
0.63
240
75
0.31
360
75
0.21
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(5)
Table H-63 provides toxicity estimates for mild effects from a percutaneous
vapor exposure to HT. Personnel are masked.
Table H-63. HT Profile Estimates (Mild Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
ECt50
Concentration
Exposure Duration
ECt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
50
25
2
25
12.5
10
50
5
10
25
2.5
30
50
1.7
30
25
0.8
60
50
0.8
60
25
0.4
120
50
0.4
120
25
0.2
240
50
0.2
240
25
0.1
360
50
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(6)
Table H-64 provides toxicity estimates for mild effects on eyes from an
ocular vapor exposure to HT.
Table H-64. HT Profile Estimates (Mild Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
25
12.5
10
25
2.5
30
25
0.8
60
25
0.4
120
25
0.2
240
25
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
H-27
f.
L Profile.
(1)
Table H-65 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to L.
Table H-65. L Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCT50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
1000
700
10
1500
10
1000
140
15
1000
30
1000
45
30
500
60
1000
25
50
300
120
1000
10
240
1000
5
360
1000
4
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(2)
Table H-66 provides toxicity estimates for a lethal dose from a
percutaneous vapor exposure to L. Personnel are masked.
Table H-66. L Profile Estimates (Lethal Dose, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
LCt50
Concentration
Exposure Duration
LCt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
5000-10,000
2500-5000
2
2500-5000
1260-2500
10
5000-10,000
500-1000
10
2500-5000
250-500
30
5000-10,000
165-330
30
2500-5000
85-165
60
5000-10,000
85-165
60
2500-5000
40-85
120
5000-10,000
40-85
120
2500-5000
20-40
240
5000-10,000
20-40
240
2500-5000
10-20
360
5000-10,000
15-30
360
2500-5000
5-15
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
True human LCt50 may be lower.
True human LCt50 may be lower.
(3)
Table H-67 provides toxicity estimates for severe effects (vesication) from a
percutaneous vapor exposure to L. Personnel are masked.
Table H-67. L Profile Estimates (Severe Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
ECt50
Concentration
Exposure Duration
ECt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
500
250
2
200
100
10
500
50
10
200
20
30
500
15
30
200
5
60
500
10
60
200
3
120
500
5
120
200
1.7
240
500
2
240
200
0.8
360
500
1.4
360
200
0.6
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
H-28
(4)
Table H-68 provides toxicity estimates for severe effects on eyes from an
ocular vapor exposure to L.
Table H-68. L Profile Estimates (Severe Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
75
37.5
10
75
7.5
30
75
2.5
60
75
1.25
120
75
0.63
240
75
0.31
360
75
0.21
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(5)
Table H-69 provides toxicity estimates for mild effects from a percutaneous
vapor exposure to L. Personnel are masked.
Table H-69. L Profile Estimates (Mild Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
ECt50
Concentration
Exposure Duration
ECt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
50
25
2
25
12.5
10
50
5
10
25
2.5
30
50
1.7
30
25
0.8
60
50
0.8
60
25
0.4
120
50
0.4
120
25
0.2
240
50
0.2
240
25
0.1
360
50
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(6)
Table H-70 provides toxicity estimates for mild effects on eyes from an
ocular vapor exposure to L.
Table H-70. L Profile Estimates (Mild Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
25
12.5
10
25
2.5
30
25
0.8
60
25
0.4
120
25
0.2
240
25
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
H-29
g.
HL Profile.
(1)
Table H-71 provides toxicity estimates for a lethal dose from an
inhalation/ocular vapor exposure to HL.
Table H-71. HL Profile Estimates (Lethal Dose, Inhalation/Ocular)1
Ct Profile (15L MV)
MV Profile (2-Minute Exposure)
Exposure Duration (min)
LCt50 (mg-min/m3)
Concentration (mg/m3)
MV (L)
LCt50 (mg-min/m3)
2
1000
500
10
1500
10
1000
170
15
1000
30
1000
80
30
500
60
1000
50
50
300
120
1000
30
240
1000
20
360
1000
15
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(2)
Table H-72 provides toxicity estimates for a lethal dose from a
percutaneous vapor exposure to HL. Personnel are masked.
Table H-72. HL Profile Estimates (Lethal Dose, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
LCt50
Concentration
Exposure Duration
LCt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
10,000
5000
2
5000
2500
10
10,000
1000
10
5000
500
30
10,000
330
30
5000
165
60
10,000
165
60
5000
85
120
10,000
85
120
5000
40
240
10,000
40
240
5000
20
360
10,000
30
360
5000
15
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(3)
Table H-73 provides toxicity estimates for severe effects (vesication) from a
percutaneous vapor exposure to HL. Personnel are masked.
Table H-73. HL Profile Estimates (Severe Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
ECt50
Concentration
Exposure Duration
ECt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
500
250
2
200
100
10
500
50
10
200
20
30
500
15
30
200
5
60
500
10
60
200
3
120
500
5
120
200
1.7
240
500
2
240
200
0.8
360
500
1.4
360
200
0.6
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
H-30
(4)
Table H-74 provides toxicity estimates for severe effects on eyes from an
ocular vapor exposure to HL.
Table H-74. HL Profile Estimates (Severe Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
75
37.5
10
75
7.5
30
75
2.5
60
75
1.25
120
75
0.63
240
75
0.31
360
75
0.21
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(5)
Table H-75 provides toxicity estimates for mild effects from a percutaneous
vapor exposure to HL. Personnel are masked.
Table H-75. HL Profile Estimates (Mild Effects, Percutaneous)1
Ct Profiles
Moderate Temperatures
Hot Temperatures
Exposure Duration
ECt50
Concentration
Exposure Duration
ECt50
Concentration
(min)
(mg-min/m3)
(mg/m3)
(min)
(mg-min/m3)
(mg/m3)
2
50
25
2
25
12.5
10
50
5
10
25
2.5
30
50
1.7
30
25
0.8
60
50
0.8
60
25
0.4
120
50
0.4
120
25
0.2
240
50
0.2
240
25
0.1
360
50
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
(6)
Table H-76 provides toxicity estimates for mild effects on eyes from an
ocular vapor exposure to HL.
Table H-76. HL Profile Estimates (Mild Effects, Ocular)1
Ct Profile
Exposure Duration (min)
ECt50 (mg-min/m3)
Concentration (mg/m3)
2
25
12.5
10
25
2.5
30
25
0.8
60
25
0.4
120
25
0.2
240
25
0.1
360
25
0.07
Selected Toxicology Information
Probit Slope: Unknown
TLE: 1 (Assumed)
DOC: Low
H-31

 

 

 

 

 

 

 

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